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CLAC3A

Summary

The cartilage-specific CLEC3A has antimicrobial activity against some of the most common nosocomial bacteria with lack of own immunogenicity and is suitable for surface coating of prostheses.

Technology Benefits

Potent antibiotic activity against both Gram-positive and Gram-negative nosocomial Bacteria
No immunogenicity due to the protein`s natural expression in cartilage
No cytotoxicity against human cell
Suitable for surface coating of prostheses and dental implants

Technology Application

Reducing infections such as those from joint replacement and dental implant surgery.

Detailed Technology Description

peptides of the cartilage-specific CLEC3A kill both Gram-positive and Gram-negative nosocomial bacteria (Figure A). Furthermore, coating these antimicrobial peptides on titanium substrates significantly reduces bacterial adhesion on titanium substrates (Figure B). Coating of prostheses and dental implants with CLEC3A-derived antimicrobial peptides could therefore be an effective way of preventing infection without cytotoxicity and immunogenicity issues.

Type of Cooperation

Licensing

Application Date

12/06/2018 00:00:00

Others

Patent application

ID No.

5125

Country/Region

Germany

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