CLAC3A
- Summary
- The cartilage-specific CLEC3A has antimicrobial activity against some of the most common nosocomial bacteria with lack of own immunogenicity and is suitable for surface coating of prostheses.
- Technology Benefits
- Potent antibiotic activity against both Gram-positive and Gram-negative nosocomial Bacteria
No immunogenicity due to the protein`s natural expression in cartilage
No cytotoxicity against human cell
Suitable for surface coating of prostheses and dental implants
- Technology Application
- Reducing infections such as those from joint replacement and dental implant surgery.
- Detailed Technology Description
- peptides of the cartilage-specific CLEC3A kill both Gram-positive and Gram-negative nosocomial bacteria (Figure A). Furthermore, coating these antimicrobial peptides on titanium substrates significantly reduces bacterial adhesion on titanium substrates (Figure B). Coating of prostheses and dental implants with CLEC3A-derived antimicrobial peptides could therefore be an effective way of preventing infection without cytotoxicity and immunogenicity issues.
- Type of Cooperation
- Licensing
- Application Date
- 12/06/2018 00:00:00
- Others
- Patent application
- ID No.
- 5125
- Country/Region
- Germany
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