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CLAC3A

总结: The cartilage-specific CLEC3A has antimicrobial activity against some of the most common nosocomial bacteria with lack of own immunogenicity and is suitable for surface coating of prostheses.

技术优势: Potent antibiotic activity against both Gram-positive and Gram-negative nosocomial Bacteria
No immunogenicity due to the protein`s natural expression in cartilage
No cytotoxicity against human cell
Suitable for surface coating of prostheses and dental implants

技术应用: Reducing infections such as those from joint replacement and dental implant surgery.

详细技术说明: peptides of the cartilage-specific CLEC3A kill both Gram-positive and Gram-negative nosocomial bacteria (Figure A). Furthermore, coating these antimicrobial peptides on titanium substrates significantly reduces bacterial adhesion on titanium substrates (Figure B). Coating of prostheses and dental implants with CLEC3A-derived antimicrobial peptides could therefore be an effective way of preventing infection without cytotoxicity and immunogenicity issues.

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