All current docking methods starting with rigid-body docking do not perform well on protein complexes with significant conformational change during formation and it is urged that new tactics should consider potential conformational changes(s) during complex formation. At present, there are no visua.....
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The present invention identifies and describes several genes that may account for at least 14% of young onset diabetes in Chinese. These include novel mutations in the glucokinase and hepatocyte nuclear factor-1 genes, as well as known mutations in the amylin gene and mitochondrial DNA. This cat.....
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The present invention identifies and describes a combination of genetic markers that are associated with increased risk for diabetic nephropathy, either independently or through interactions with obesity, blood pressure and lipid controls. These polymorphisms include the lipoprotein lipase (Ser447T.....
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