A Catalogue of Chinese-relevant Markers for Diabetic Nephropathy
- Summary
- The present invention identifies and describes a combination of genetic markers that are associated with increased risk for diabetic nephropathy, either independently or through interactions with obesity, blood pressure and lipid controls. These polymorphisms include the lipoprotein lipase (Ser447Term), paraoxonase 1 (Met55Leu), paraoxonase 2 (Ser311Cys), G protein beta-3 subunit (C825T), apolipoprotein B (Thr71Ile), beta-3 adrenergic receptor (Trp64Arg) and hepatic lipase (C-480T). In addition, polymorphisms of apoliprotein B (Thr71Ile), endothelial nitric oxide synthase (A-922G), stromelysin (5A/6A), angiotensin II receptor type 1 (A1166C), angiotensinogen (Met235Thr) and G protein beta-3 subunit (C825T) are associated with risk for dyslipidaemia either at the presence or absence of diabetic nephropathy. This catalogue of genetic markers can be used as a diagnostic tool to identify subjects predisposed to diabetic nephropathy and dyslipidaemia.
- Industry
- Biomedical
- Sub Category
- DNA/Gene Engineering
- Application No.
- 02/MED/097
- Others
- Inventor(s): Professor Juliana C N Chan, Department of Medicine & Therapeutics
Patent Status: Chinese Patent Pending Hong Kong Patent Pending
Licensing Status: Available for Licensing
- Country/Region
- Hong Kong
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