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Combinatorial Transcription Control

Technology Application

The potential of programming genetic responses “at will” using this approach offers a multitude of applications in bioengineering, biomedicine, molecular agriculture, and other fields that benefit from manipulation of gene expression. For instance, it can be designed to detect specific gene expression patterns associated with hazardous, defective, degenerative, enhancing, or regenerative factors in organisms ranging from bacteria to humans, and thereby allowing the targeted expression of genes for reporting or therapeutic purposes.

Detailed Technology Description

UC San Diego inventors have developed strategies and methods for exertion of combinatorial control on gene expression by integrating multiple transcription signals directly in the regulatory region without the need for additional genes and their expressions. (See White Paper PDF below for additional details.)

Supplementary Information

Patent Number: US8301387B2
Application Number: US2003537950A
Inventor: Hwa, Terence Tai-Li | Gerland, Ulrich | Buchler, Nicolas
Priority Date: 9 Dec 2002
Priority Number: US8301387B2
Application Date: 8 Jun 2005
Publication Date: 30 Oct 2012
IPC Current: G01N003348 | C12N001563 | C12Q000168 | G01N003100 | G01N003350 | G06F001900 | G06N000312
US Class: 702019 | 4350061 | 702020 | 702022
Assignee Applicant: The Regents of the University of California
Title: Combinatorial transcription control for programmed genetic response
Usefulness: Combinatorial transcription control for programmed genetic response
Summary: The method is used for controlling the transcription of target genes and for genetic computing using combinatorial transcription for controlling gene expression (claimed).
Novelty: Encoding controlled functions in regulatory DNA sequences to exert combinatorial transcription control, involves selecting strength of binding sites of transcription factors and their positioning to implement several different logic functions