F-Cyclo - Carbene-catalysed aryl hydrogenation to cyclohexanes with fluorine substituents
- Summary
- An efficient manufacturing process or fluorinated cyclohexane derivatives and related heterocycles
- Technology Benefits
- Selective synthesis
High yields
All-cis orientation
Access for pharmaceutically interesting substances
Different substituents possible
- Technology Application
- Fluorinated cyclohexane derivatives are used as a raw material for pharmaceutically active substances and have been chemically accessible only in low yields until now . Such compounds play a major role in the pharmaceutical or agrochemical field due to the polarity of the C-F bond with concomitant steric similarity to C-H bonds and other effects
- Detailed Technology Description
- An efficient manufacturing process for fluorinated cyclohexane derivatives and related heterocycles is obtained by hydrogenation of fluorinated aromatics with the help of rhodium carbene catalysts. Thus, fluorinated all-cis cyclohexane derivatives are readily prepared by direct hydrogenation of the fluoroaromatics.
- Type of Cooperation
- Licensing
- Application Date
- 27/03/2017 00:00:00
- Application No.
- WO2018EP54554 20180223
- Classes
- - international:
C07C17/354; C07C23/10; C07C69/75
- cooperative:
C07B31/00; C07C17/354; C07C41/20; C07C67/303; C07F15/0086; C07F5/04; C07F7/0803; C07F7/1804; C07B2200/09; C07C2601/14; C07J1/0059; C07J15/00 more
- Others
- Patent application
- ID No.
- 4980
- Country/Region
- Germany
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