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F-Cyclo - Carbene-catalysed aryl hydrogenation to cyclohexanes with fluorine substituents

总结

An efficient manufacturing process or fluorinated cyclohexane derivatives and related heterocycles

技术优势

Selective synthesis
High yields
All-cis orientation
Access for pharmaceutically interesting substances
Different substituents possible

技术应用

Fluorinated cyclohexane derivatives are used as a raw material for pharmaceutically active substances and have been chemically accessible only in low yields until now . Such compounds play a major role in the pharmaceutical or agrochemical field due to the polarity of the C-F bond with concomitant steric similarity to C-H bonds and other effects

详细技术说明

An efficient manufacturing process for fluorinated cyclohexane derivatives and related heterocycles is obtained by hydrogenation of fluorinated aromatics with the help of rhodium carbene catalysts. Thus, fluorinated all-cis cyclohexane derivatives are readily prepared by direct hydrogenation of the fluoroaromatics.

合作类型

Licensing

申请日期

27/03/2017 00:00:00

申请号码

WO2018EP54554 20180223

分类

- international:
C07C17/354; C07C23/10; C07C69/75

- cooperative:

C07B31/00; C07C17/354; C07C41/20; C07C67/303; C07F15/0086; C07F5/04; C07F7/0803; C07F7/1804; C07B2200/09; C07C2601/14; C07J1/0059; C07J15/00 more

其他

Patent application

ID号码

4980

国家/地区

德国