ET-CORMs
- Summary
- A novel class of iron carbonyl complexes, which release their CO load only after enzymatic activation.
- Technology Benefits
- Acyl-oxydiene-Fe(CO)3 complexes are an innovative class of ET-CORMs allowing for the first time a controlled intracellular and potentially tissue-specific CO-release
First water-soluble enzyme-triggered CO-releasing molecules
ET-CORMs open new perspectives for the prevention and cure of diseases involving inflammatory, infectious, thrombotic or proliferative processes
- Technology Application
- CO-releasing molecules have the potential to become an important new class of drugs in the future. . The delivery of small amounts of CO to tissues can widen blood vessels, increase blood flow, prevent unwanted blood clotting, reduce inflammation and even suppress immune responses and the activity of cells and macrophages which attack transplanted organs.
- Detailed Technology Description
- the invention comprises a novel class of iron carbonyl complexes, which release their CO load only after enzymatic activation. The powerful CO-releasing properties and the structural variability form a promising basis for the development of safe and pharmacologically useful CO-releasing molecules (CORMs).
- Type of Cooperation
- Licensing
- Application Date
- 04/02/2011 00:00:00
- Application No.
- US201113020933 2011020
- Classes
- - international:
A61K31/295; A61K31/555; A61K31/575; A61K31/695; A61P11/00; A61P25/28; A61P29/00; A61P35/00; A61P9/08; A61P9/10; A61P9/12; C07F15/02
- cooperative:
C07F17/02; C07F7/0805; C07F7/1804
- Others
- Patent application
- ID No.
- 2644
- Country/Region
- Germany
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