Media.Player

ET-CORMs

总结

A novel class of iron carbonyl complexes, which release their CO load only after enzymatic activation.

技术优势

Acyl-oxydiene-Fe(CO)3 complexes are an innovative class of ET-CORMs allowing for the first time a controlled intracellular and potentially tissue-specific CO-release
First water-soluble enzyme-triggered CO-releasing molecules
ET-CORMs open new perspectives for the prevention and cure of diseases involving inflammatory, infectious, thrombotic or proliferative processes

技术应用

CO-releasing molecules have the potential to become an important new class of drugs in the future. . The delivery of small amounts of CO to tissues can widen blood vessels, increase blood flow, prevent unwanted blood clotting, reduce inflammation and even suppress immune responses and the activity of cells and macrophages which attack transplanted organs.

详细技术说明

the invention comprises a novel class of iron carbonyl complexes, which release their CO load only after enzymatic activation. The powerful CO-releasing properties and the structural variability form a promising basis for the development of safe and pharmacologically useful CO-releasing molecules (CORMs).

合作类型

Licensing

申请日期

04/02/2011 00:00:00

申请号码

US201113020933 2011020

分类

- international:
A61K31/295; A61K31/555; A61K31/575; A61K31/695; A61P11/00; A61P25/28; A61P29/00; A61P35/00; A61P9/08; A61P9/10; A61P9/12; C07F15/02
- cooperative:
C07F17/02; C07F7/0805; C07F7/1804

其他

Patent application

ID号码

2644

国家/地区

德国