Novel Gene Delivery Method
Researchers at Purdue University have developed a new technology that supports the replication of bovine adenoviral vector with full E1 region deleted. This allows foreign gene cassette capacity in the bovine adenoviral vector to be extended by 2kb. Such deletion would allow for a much greater insert capacity of the foreign gene cassette containing one or more genes. This new technology could potentially open the door for many new technologies pertaining to adenoviral vector mediated gene delivery and vaccine production.
Provides better responsesMore efficient
Gene deliveryAdenoviral vectorsGene therapy
Suresh MittalPurdue Comparative Pathobiology
United States
Inventor: Boye, Sanford Leon | Hauswirth, William W. | Byrne, Barry John
Priority Number: US8298818B2
IPC Current: C12N001500 | C12N000500
US Class: 4353201 | 435325
Assignee Applicant: University of Florida Research Foundation Inc.inesville
Title: Self-complementary adeno-associated virus having a truncated CMV-chicken &bgr;-actin promoter | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
Usefulness: Self-complementary adeno-associated virus having a truncated CMV-chicken &bgr;-actin promoter | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
Summary: As pharmaceutical composition for delivering polynucleotide to a cell such as human cell or non-human animal cell including brain cell, liver cell, lung cell, cardiac cell, ocular cell, smooth muscle cell and neuron (all claimed) for treating or delaying onset of infection.
Novelty: Novel vector comprising truncated chimeric cytomegalovirus CMV-chicken beta-actin promoter, useful for delivering polynucleotide to cell such as human cell or non-human animal cell
Biomedical
DNA/Gene Engineering
None
USA
