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Novel Gene Delivery Method

總結

Researchers at Purdue University have developed a new technology that supports the replication of bovine adenoviral vector with full E1 region deleted.  This allows foreign gene cassette capacity in the bovine adenoviral vector to be extended by 2kb.  Such deletion would allow for a much greater insert capacity of the foreign gene cassette containing one or more genes.  This new technology could potentially open the door for many new technologies pertaining to adenoviral vector mediated gene delivery and vaccine production.

技術優勢

Provides better responsesMore efficient

技術應用

Gene deliveryAdenoviral vectorsGene therapy

詳細技術說明

Suresh MittalPurdue Comparative Pathobiology

*Abstract

None

*Background

In the current versions of bovine adenoviral vector system, only .6 kb deletion of the E1 region can be made in the bovine cell line.  Various versions of less prevalent human adenoviral vectors are tested for gene delivery and vaccine production.  The problem with these current versions is that they do not provide the best immune responses.  They are also not as efficient as they could be.  There is a need for a new technology that allows for better responses and increases the efficiency of adenoviral vector mediated gene delivery.

*IP Issue Date

None

*IP Type

Provisional

*Stage of Development

Concept validated through theory, simulation, or models

*Web Links

Purdue Office of Technology CommercializationPurdue Innovation and EntrepreneurshipSuresh MittalPurdue Comparative Pathobiology

國家

United States

附加資料

Inventor: Boye, Sanford Leon | Hauswirth, William W. | Byrne, Barry John
Priority Number: US8298818B2
IPC Current: C12N001500 | C12N000500
US Class: 4353201 | 435325
Assignee Applicant: University of Florida Research Foundation Inc.inesville
Title: Self-complementary adeno-associated virus having a truncated CMV-chicken &bgr;-actin promoter | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
Usefulness: Self-complementary adeno-associated virus having a truncated CMV-chicken &bgr;-actin promoter | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
Summary: As pharmaceutical composition for delivering polynucleotide to a cell such as human cell or non-human animal cell including brain cell, liver cell, lung cell, cardiac cell, ocular cell, smooth muscle cell and neuron (all claimed) for treating or delaying onset of infection.
Novelty: Novel vector comprising truncated chimeric cytomegalovirus CMV-chicken beta-actin promoter, useful for delivering polynucleotide to cell such as human cell or non-human animal cell

主要類別

生物醫學

細分類別

DNA /基因工程

申請號碼

None

國家/地區

美國