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4(1H)-Quinolones Having Anti-Malarial Activity with Reduced Chemical Resistance
Technology Benefits
Potent anti-malarial activityImproved chemical resistance against multi-drug resistant (MDR) parasitesActs on both MDR parasites and drug susceptible anti-malarial strains equally well
Technology Application
antimalarial drugs
Detailed Technology Description
This invention promises a great approach to treat those affected with malaria. The compound possesses a potent EC50 against multidrug resistant malarial strains W2 (chloroquine and pyrimethamine resistant) and TM90-C2B (chloroquine, mefloquine, pyrimethamine, and atovaquone resistant). This compound also exhibits signs of reduced chemical resistance.
Country/Region
USA
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