Monoclonal Antibodies Against Tumor Necrosis Factor (TNF-α; 3 lines)
- Detailed Technology Description
- Applications Tumor necrosis factor is a cell signaling protein orcytokine that is involved in inflammation, and specifically one of the proteinsin the acute phase reaction. TNF is produced mainly by macrophages but otherwhite cells too. Some of its roles are to induce fever, apoptotic cell death,inhibit tumorigenesis and inflammation. Diseases associated with dysregulationof TNF production include inflammatory bowel disease (IBD), Psoriasis,Alzheimer's and cancer. Validated for use in WB and ELISA. Some cross-reactivity observed with rHTNFα. None with nETNFß, nMTNFα, rMTNFß and rPTNFα
- *Abstract
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ReagentDescription
Antigen:
TNF
Line name (Isotype)
6H4.E1 (IgG2b); 9B10 (IgG2b); 12F6 (IgG1)
Reactivity:
Equine, related species
Immunogen:
Protein
Species Immunized:
Mouse
Buffer:
0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide
Tested Applications:
ELISA, WB, IP, Competitive ELISA
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References
SuX, Morris DD, Crowe NA, Moore JN, Fischer KJ, McGraw RA. Equine tumor necrosisfactor alpha: cloning and expression in Escherichia coli, generation ofmonoclonal antibodies, and development of a sensitive enzyme-linkedimmunosorbent assay. Hybridoma. 1992Dec. 11(6):715-27
- Country/Region
- USA
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