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Novel Mithramycin Derivatives for Cancer Chemotherapy (2198)
Technology Benefits
Key Advantages • Improved selectivity for betterefficacy and fewer off-target effects• Potential for less toxicity thanavailable chemotherapeutic agents currently in the clinic• Better pharmacological propertiesthan current chemotherapies in use today
Detailed Technology Description
The University of Kentucky is seeking a partner to further develop and commercializevarious mithramycin SA derivatives that were synthesized from a mithramycinSA-producing mutant. The derivatives of particular interest are thosecontaining the dipeptides L-Phe and L-Trp, and provide the potential for moreefficacious and less toxic chemotherapeutic interventions for Ewing’s Sarcoma.
Country/Region
USA
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