Butylcholinesterase Mutants for Cocaine Hydrolysis - 1742
- Technology Benefits
- Inventionuses variants of butylcholinesterase that have enhanced catalytic efficiencyfor (-)-cocaine in order to lower blood concentrations of cocaine. Thecatalytic activity of these variant enzymes are orders-of-magnitude highercompared to wildtype BChE and can more efficiently clear (-)-cocaine, which hasa much longer half-life compared to (+)-cocaine, from the blood.
- Detailed Technology Description
- None
- *Abstract
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None
- Country/Region
- USA
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