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Weaponizing Immune Cells with New Liposomes to Target Metastatic Cancer

Detailed Technology Description

Thisinvention describes a method to functionalized cells using liposomenanoparticles for inhibiting metastatic cancer cells.

Others

PatentApplication US20160184395.
Wayne,E.C. & al. (2016). TRAIL-coated leukocytes that prevent the bloodbornemetastasis of prostate cancer. Journal ofControlled Release Vol.223:215–223. DOI: 10.1016/j.jconrel.2015.12.048
Mitchell,M.J. & King, M.R. (2015). Leukocytes as carriers for targeted cancer drugdelivery. Expert Opin. Drug Deliv. Vol.12(3):375-392.DOI: 10.1517/17425247.2015.966684
Mitchell,M.J. & al. (2014). TRAIL-coated leukocytes that kill cancer cells in thecirculation. PNAS 111(3):930-5. DOI: 10.1073/pnas.1316312111
Chandrasekaran,S. & al. (2014). Sweeping lymph node micrometastases off their feet: anengineered model to evaluate natural killer cell mediated therapeuticintervention of circulating tumor cells that disseminate to the lymph nodes. Lab Chip 14, 118-127. DOI: 10.1039/C3LC50584G
“Proteins seek, attack, destroy tumor cells inbloodstream” Cornell Chronicle – B. Friedlander, Jan.12, 2016
Cornell BioMedical Engineers Develop Cells toKill Cancer” TWC News – P. O'Driscoll, Nov. 21, 2015
“'Super natural killer cells' destroy lymphnode tumors” Cornell Chronicle – B. Friedlander, Nov.12,2015
‘Metastatic cancer cells implode on proteincontact’ Cornell Chronicle – B. Friedlander - Jan.6, 2014.

Country/Region

USA

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