Weaponizing Immune Cells with New Liposomes to Target Metastatic Cancer
- 详细技术说明
- Thisinvention describes a method to functionalized cells using liposomenanoparticles for inhibiting metastatic cancer cells.
- *Abstract
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Circulating blood cells are functionalized directly in vivo, which then adhere to circulating tumor, immune, or other cells for the treatment of metastasis, inflammation, and other conditions.
In one embodiment, Cornell researchers have used this approach to capture and kill circulating tumor cells (CTC) in blood and lymphatic vessels. Leukocytes were functionalized with TRAIL-decorated liposome nanoparticles. These leukocytes, bound to CTC, then induce apoptosis, thereby eliminating CTC from circulation.
Since greater than 90% of cancer related deaths are caused by metastasis, this technology offers a potentially important treatment in an area of significant and unmet need.
Additional potential applications for this approach include use of other decorated nanoparticles for various types of cancer treatment, as well as for anti-inflammatory conditions. A further utilization of this technology involves its use in imaging techniques.
Potential Commercial Applications:
- Treatment for highly metastatic cancers such as breast, prostate, and lung cancer
- Treatment for inflammation
Advantages
Representsa major breakthrough in cancer treatment, as there are no existing technologiesthat can both capture and kill CTC in vivo.
- *Licensing
- Jeff Fearnjcf55@cornell.edu607-254-4502
- 其他
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- PatentApplication US20160184395.
- Wayne,E.C. & al. (2016). TRAIL-coated leukocytes that prevent the bloodbornemetastasis of prostate cancer. Journal ofControlled Release Vol.223:215–223. DOI: 10.1016/j.jconrel.2015.12.048
- Mitchell,M.J. & King, M.R. (2015). Leukocytes as carriers for targeted cancer drugdelivery. Expert Opin. Drug Deliv. Vol.12(3):375-392.DOI: 10.1517/17425247.2015.966684
- Mitchell,M.J. & al. (2014). TRAIL-coated leukocytes that kill cancer cells in thecirculation. PNAS 111(3):930-5. DOI: 10.1073/pnas.1316312111
- Chandrasekaran,S. & al. (2014). Sweeping lymph node micrometastases off their feet: anengineered model to evaluate natural killer cell mediated therapeuticintervention of circulating tumor cells that disseminate to the lymph nodes. Lab Chip 14, 118-127. DOI: 10.1039/C3LC50584G
- “Proteins seek, attack, destroy tumor cells inbloodstream” Cornell Chronicle – B. Friedlander, Jan.12, 2016
- Cornell BioMedical Engineers Develop Cells toKill Cancer” TWC News – P. O'Driscoll, Nov. 21, 2015
- “'Super natural killer cells' destroy lymphnode tumors” Cornell Chronicle – B. Friedlander, Nov.12,2015
- ‘Metastatic cancer cells implode on proteincontact’ Cornell Chronicle – B. Friedlander - Jan.6, 2014.
- 国家/地区
- 美国
