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Methods to drive differentiation of stem cells to neurons or glial cells

Others
(2006) Sim FJ et al. Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol. 59(5):763-79.

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=16634042[uid]

(2007) Goldman SA. Disease targets and strategies for the therapeutic modulation of endogenous neural stem and progenitor cells. Clin Pharmacol Ther. 82(4):453-60.

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=17713467[uid]

(2008) Sim FJ, et al. Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation. Glia 56(9):954-62.

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=18383345[uid]
*Abstract
  • Targets for discovering drugs to drive stem cell differentiation to neurons or glial cells
  • Repurposing of drugs already known to modulate these targets (e.g. statins)
  • Methods to drive or prevent endogenous neurogenesis using drugs that modulate these targets
  • Methods to drive or prevent differentiation in vitro

Dr. Goldman's team discovered that a small percentage of cells found in the subcortical white matter are neural progenitor cells (Cornell docket D-3221). More recently, by performing microarray analysis of adult human subcortical white matter, followed by confirmatory real-time RT-PCR analysis, his team identified the autocrine signals and receptors by which these cells maintain their multipotential and mitotically-competent state. As such, these molecules provide targets for developing drugs to prevent or promote in situ endogenous neurogenesis, or to manipulate cells in vitro.

 

The key receptor-ligand pair is receptor protein tyrosine phosphatase zeta /beta and pleiotrophin. Also, certain cell adhesion molecules known to associate with RPTP zeta/beta , namely, Nr-cam, L1/NgCam, are upregulated as well. Finally, the invention teaches that inhibitors of sterol synthesis, such as statins, drives differentiation in this population of cells.
*Licensing
Dan-Oscar Antsonda429@cornell.edu212-746-1297
Country/Region
USA

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