Methods to drive differentiation of stem cells to neurons or glial cells
- *Abstract
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- Targets for discovering drugs to drive stem cell differentiation to neurons or glial cells
- Repurposing of drugs already known to modulate these targets (e.g. statins)
- Methods to drive or prevent endogenous neurogenesis using drugs that modulate these targets
- Methods to drive or prevent differentiation in vitro
Dr. Goldman's team discovered that a small percentage of cells found in the subcortical white matter are neural progenitor cells (Cornell docket D-3221). More recently, by performing microarray analysis of adult human subcortical white matter, followed by confirmatory real-time RT-PCR analysis, his team identified the autocrine signals and receptors by which these cells maintain their multipotential and mitotically-competent state. As such, these molecules provide targets for developing drugs to prevent or promote in situ endogenous neurogenesis, or to manipulate cells in vitro.
The key receptor-ligand pair is receptor protein tyrosine phosphatase zeta /beta and pleiotrophin. Also, certain cell adhesion molecules known to associate with RPTP zeta/beta , namely, Nr-cam, L1/NgCam, are upregulated as well. Finally, the invention teaches that inhibitors of sterol synthesis, such as statins, drives differentiation in this population of cells.
- *Licensing
- Dan-Oscar Antsonda429@cornell.edu212-746-1297
- 其他
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(2006) Sim FJ et al. Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol. 59(5):763-79.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=16634042[uid]
(2007) Goldman SA. Disease targets and strategies for the therapeutic modulation of endogenous neural stem and progenitor cells. Clin Pharmacol Ther. 82(4):453-60.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=17713467[uid]
(2008) Sim FJ, et al. Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation. Glia 56(9):954-62.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=18383345[uid]
- 國家/地區
- 美國
