Peptide Mimotopes to Oxidation Specific Epitopes
- Technology Application
- In conjunction with different carriers, the newly identified peptides can be used as immunogens to study the mechanistic role of MDA-specific immune responses in immunization studies, and may provide the basis for potential atheroprotective vaccines, and could also be useful as imaging agents for inflammatory sites and/or atherosclerotic lesions.
- Detailed Technology Description
- UCSD researchers have identified two peptide mimotopes that form a three dimensional representation of critical epitopes of MDA. These mimotopes have been shown to be representative of oxidation-specific epitopes that are proinflammatory and proatherogenic.
- Industry
- Chemical/Material
- Sub Category
- Chemical/Material Application
- Others
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Tech ID/UC Case
22613/2012-183-0
Related Cases
2012-183-0
- *Abstract
-
Autoantibodies specific for malondialdehyde-modified LDL (MDA-LDL) represent potential biomarkers to predict cardiovascular risk. However, MDA-LDL is a high variability antigen with limited reproducibility. To identify peptide mimotopes of MDA-LDL, phage display libraries were screened and the specificity and antigenic properties of MDA mimotopes were assessed in vitro and in vivo.
- *Principal Investigator
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Name: Shahzada Amir
Department:
Name: Christoph Binder
Department:
Name: Sotirios Tsimikas
Department:
Name: Joseph Witztum
Department:
- Country/Region
- USA
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