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Peptide Mimotopes to Oxidation Specific Epitopes

技术应用

In conjunction with different carriers, the newly identified peptides can be used as immunogens to study the mechanistic role of MDA-specific immune responses in immunization studies, and may provide the basis for potential atheroprotective vaccines, and could also be useful as imaging agents for inflammatory sites and/or atherosclerotic lesions.

详细技术说明

UCSD researchers have identified two peptide mimotopes that form a three dimensional representation of critical epitopes of MDA. These mimotopes have been shown to be representative of oxidation-specific epitopes that are proinflammatory and proatherogenic.

*Abstract

Autoantibodies specific for malondialdehyde-modified LDL (MDA-LDL) represent potential biomarkers to predict cardiovascular risk. However, MDA-LDL is a high variability antigen with limited reproducibility. To identify peptide mimotopes of MDA-LDL, phage display libraries were screened and the specificity and antigenic properties of MDA mimotopes were assessed in vitro and in vivo.

*Principal Investigation

Name: Shahzada Amir

Department:

Name: Christoph Binder

Department:

Name: Sotirios Tsimikas

Department:

Name: Joseph Witztum

Department:

主要类别

化工/材料

细分类别

化工/材料应用

其他

Tech ID/UC Case

22613/2012-183-0

Related Cases

2012-183-0

国家/地区

美国