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Device for Detection of Organic Compounds, Ions, and Other Molecular Species by Optical Interference in a Porous Silicon Layer

Technology Benefits

This invention has excellent applications to homogeneous assay systems because organic compounds can be detected in solutions without separating them, removing the burdensome step of washing out the compounds. This method may be performed using nanoliters of reactants.

Detailed Technology Description

This chemistry provides a means to sensitively measure the quantity of a chemical compound or element of interest (analyte) by measuring the effect it has on the optical interference spectrum from a layer of porous silicon that may or may not have been modified to enhance the binding of the analyte.

Supplementary Information

Patent Number: US6248539B1
Application Number: US1997961308A
Inventor: Ghadiri, M. Reza | Motesharei, Kianoush | Lin, Shang Yi | Sailor, Michael J. | Dancil, Keiki Pua S.
Priority Date: 5 Sep 1997
Priority Number: US6248539B1
Application Date: 30 Oct 1997
Publication Date: 19 Jun 2001
IPC Current: G01N0033543
US Class: 4350071 | 385012 | 385129 | 385130 | 42208211 | 4352871 | 4352872 | 4352887 | 435808 | 435973 | 436164 | 436165 | 436518 | 436527 | 436805 | 356345 | 356352 | 42205205
Assignee Applicant: The Scripps Research InstituteJolla | The Regents of the University of California at San DiegoJolla
Title: Porous semiconductor-based optical interferometric sensor
Usefulness: Porous semiconductor-based optical interferometric sensor
Summary: USE The methods can be used for the highly sensitive detection, identification and quantification of small molecules and particularly small organic molecules (e.g. carbon-containing molecules, e.g. biotin, and the steroid digoxigenin), short DNA oligonucleotides (e.g. 16-mers), and proteins (e.g. streptavidin and antibodies), or inorganic species such as metal ions.
Novelty: New assays for the detection of analytes using a porous semiconductor substrate having a binder compound associated with it and using Fabry-Perot fringe wavelength measurement

Industry

Biomedical

Sub Category

Medical Device

Application No.

6248539

Others

Related Materials

• View Professor Michael Sailor's Smart Dust presentation June 2005.
• See Sailor lab link at http://chem-faculty.ucsd.edu/sailor/research.

Tech ID/UC Case

19556/1997-064-0

Related Cases

1997-064-0

*Abstract

Combinatorial chemistry is arguably the most important development in the drug discovery process in over a decade. However, the detection of significant biological events in high throughput screening involves many burdensome tasks, and often includes the separation of the products of reaction before detection can take place.

*IP Issue Date

Jun 19, 2001

*Principal Investigator

Name: Keiki-Pua Dancil

Department:

Name: M. REZA GHADIRI

Department:

Name: SHANG-YI LIN

Department:

Name: KIANOUSH MOTESHAREI

Department:

Name: Michael Sailor

Department:

Country/Region

USA