Device for Detection of Organic Compounds, Ions, and Other Molecular Species by Optical Interference in a Porous Silicon Layer
This invention has excellent applications to homogeneous assay systems because organic compounds can be detected in solutions without separating them, removing the burdensome step of washing out the compounds. This method may be performed using nanoliters of reactants.
This chemistry provides a means to sensitively measure the quantity of a chemical compound or element of interest (analyte) by measuring the effect it has on the optical interference spectrum from a layer of porous silicon that may or may not have been modified to enhance the binding of the analyte.
Patent Number: US6248539B1
Application Number: US1997961308A
Inventor: Ghadiri, M. Reza | Motesharei, Kianoush | Lin, Shang Yi | Sailor, Michael J. | Dancil, Keiki Pua S.
Priority Date: 5 Sep 1997
Priority Number: US6248539B1
Application Date: 30 Oct 1997
Publication Date: 19 Jun 2001
IPC Current: G01N0033543
US Class: 4350071 | 385012 | 385129 | 385130 | 42208211 | 4352871 | 4352872 | 4352887 | 435808 | 435973 | 436164 | 436165 | 436518 | 436527 | 436805 | 356345 | 356352 | 42205205
Assignee Applicant: The Scripps Research InstituteJolla | The Regents of the University of California at San DiegoJolla
Title: Porous semiconductor-based optical interferometric sensor
Usefulness: Porous semiconductor-based optical interferometric sensor
Summary: USE The methods can be used for the highly sensitive detection, identification and quantification of small molecules and particularly small organic molecules (e.g. carbon-containing molecules, e.g. biotin, and the steroid digoxigenin), short DNA oligonucleotides (e.g. 16-mers), and proteins (e.g. streptavidin and antibodies), or inorganic species such as metal ions.
Novelty: New assays for the detection of analytes using a porous semiconductor substrate having a binder compound associated with it and using Fabry-Perot fringe wavelength measurement
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6248539
Related Materials Tech ID/UC Case 19556/1997-064-0 Related Cases 1997-064-0
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