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Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase

Technology Application

This discovery provides for drug discovery and design protocols for isoform drugs that target NOS isoforms and reduce NO production.

Detailed Technology Description

University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric oxide (NO). X-ray crystallography was utilized to generate isoform specific NOS-inhibitor complexes with unique structural characteristics. An overproduction of NO has been linked to several diseases, conditions and addictions, including: ischemic injury and other brain damage after stroke, migraine headache, Alzheimer's Disease, colitis, tissue damage, inflammation, septic shock and rheumatoid arthritis.

Supplementary Information

Patent Number: US7056945B1
Application Number: US2003463213A
Inventor: Poulos, Thomas | Li, Huiying | Flinspach, Mack
Priority Date: 14 Jun 2002
Priority Number: US7056945B1
Application Date: 17 Jun 2003
Publication Date: 6 Jun 2006
IPC Current: A61K003140 | A61K003116
US Class: 514428 | 514429 | 514614
Assignee Applicant: The Regents of the University of California
Title: Selective inhibition of neuronal nitric oxide synthase
Usefulness: Selective inhibition of neuronal nitric oxide synthase
Summary: (A) is useful to treat or prevent disorder in human or veterinary patient mediated by neuronal nitric oxide synthase (nNOS) inhibitor (claimed).
Novelty: Composition, useful to treat or prevent disorder in human or veterinary patient mediated by neuronal nitric oxide synthase inhibitor, comprises nitro-aminoimine compounds

Industry

Biomedical

Sub Category

Medical Composition

Application No.

7056945

Others

Tech ID/UC Case

18881/2002-460-0

Related Cases

2002-460-0

*Abstract

*IP Issue Date

Jun 6, 2006

*Principal Investigator

Name: Mack Flinspach III

Department:

Name: Huiying Li

Department:

Name: Thomas Poulos

Department:

Country/Region

USA