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Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase

技术应用: This discovery provides for drug discovery and design protocols for isoform drugs that target NOS isoforms and reduce NO production.

详细技术说明: University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric oxide (NO). X-ray crystallography was utilized to generate isoform specific NOS-inhibitor complexes with unique structural characteristics. An overproduction of NO has been linked to several diseases, conditions and addictions, including: ischemic injury and other brain damage after stroke, migraine headache, Alzheimer's Disease, colitis, tissue damage, inflammation, septic shock and rheumatoid arthritis.

*Principal Investigation: Name: Mack Flinspach III
Department:

Name: Huiying Li
Department:

Name: Thomas Poulos
Department:

附加资料: Patent Number: US7056945B1
Application Number: US2003463213A
Inventor: Poulos, Thomas | Li, Huiying | Flinspach, Mack
Priority Date: 14 Jun 2002
Priority Number: US7056945B1
Application Date: 17 Jun 2003
Publication Date: 6 Jun 2006
IPC Current: A61K003140 | A61K003116
US Class: 514428 | 514429 | 514614
Assignee Applicant: The Regents of the University of California
Title: Selective inhibition of neuronal nitric oxide synthase
Usefulness: Selective inhibition of neuronal nitric oxide synthase
Summary: (A) is useful to treat or prevent disorder in human or veterinary patient mediated by neuronal nitric oxide synthase (nNOS) inhibitor (claimed).
Novelty: Composition, useful to treat or prevent disorder in human or veterinary patient mediated by neuronal nitric oxide synthase inhibitor, comprises nitro-aminoimine compounds

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