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Real Time Adaptive External Immune System

Technology Benefits

Array platform allows for multiple targets to be used simultaneously, increases sensitivity and increases speed of diagnosis Ability to bind a vast range of targets in real time Can "communicate" with the innate immune system to induce an immune response without introducing foreign bodies (e.g. vaccines) into the body Bind and remove pathogens that have become multi-drug resistant or do not have effective vaccines Multiple targets can be used simultaneously, reducing diagnosis time and required sample volume

Technology Application

Capture of blood-borne parasites that effect both detection and removal of parasites Capture and removal of cytokines to reduce the life-threatening effects of shock Immune stimulation for cancer, bacterial, or parasitic infections by presenting immune activation signals to bodily fluids Generation of human antibody targets Release of therapeutic agents into bodily fluids Diagnosis of disease and monitoring of vital systems External apparatus for real-time filtering of targets such as pathogens, proteins, and endotoxins from patient body fluid Generation of an immune response (modified vaccination) in body fluids without introducing foreign agents into the body Diagnosis tool for disease agents or body-fluid-borne markers

Detailed Technology Description

Current methods to remove unwanted agents from bodily fluids (e.g. plasmapheresis) do not occur real-time and induce negative side effects such as transfusion reactions and clotting complications. Other methods such as dialysis fail to remove many targets of high interest such as pathogens, viruses, bacteria, cytokines, cell lines, proteins, endotoxins, and particulates. Researchers at the University of California, Davis have developed a novel system using nanotechnology to synthetically replicate the body's immune function. The method involves the binding of a wide range of targets to nanoparticles over which bodily fluids are passed for filtration, diagnostic, or immune stimulation functions. Initial results using particles coated with CD14 antibody in rhesus macaques successfully resulted in the conversion of target monocytes to functional macrophages. This result demonstrates the immune modulation properties of the system as well as the possibility of manipulating captured cell lines that retain functionality for further therapeutic use. It also demonstrates the novel possibility of using cross-species targets to generate an immune response which is achievable because of the external presentation of the targets.

Application No.

20130303960

Others

Tech ID/UC Case

21394/2010-523-0

Related Cases

2010-523-0

*Abstract

Researchers at the University of California, Davis have developed a system to synthetically replicate the body's immune function.

*IP Issue Date

Nov 14, 2013

*Principal Investigator

Name: Angela Courtney

Department:

Name: Abigail Spinner

Department:

Country/Region

USA