亞洲知識產權資訊網為知識產權業界提供一個一站式網上交易平台，協助業界發掘知識產權貿易商機，並與環球知識產權業界建立聯繫。無論你是知識產權擁有者正在出售您的知識產權，或是製造商需要購買技術以提高操作效能，又或是知識產權配套服務供應商，你將會從本網站發掘到有用的知識產權貿易資訊。

返回搜索結果

Real Time Adaptive External Immune System

技術優勢: Array platform allows for multiple targets to be used simultaneously, increases sensitivity and increases speed of diagnosis Ability to bind a vast range of targets in real time Can "communicate" with the innate immune system to induce an immune response without introducing foreign bodies (e.g. vaccines) into the body Bind and remove pathogens that have become multi-drug resistant or do not have effective vaccines Multiple targets can be used simultaneously, reducing diagnosis time and required sample volume

技術應用: Capture of blood-borne parasites that effect both detection and removal of parasites Capture and removal of cytokines to reduce the life-threatening effects of shock Immune stimulation for cancer, bacterial, or parasitic infections by presenting immune activation signals to bodily fluids Generation of human antibody targets Release of therapeutic agents into bodily fluids Diagnosis of disease and monitoring of vital systems External apparatus for real-time filtering of targets such as pathogens, proteins, and endotoxins from patient body fluid Generation of an immune response (modified vaccination) in body fluids without introducing foreign agents into the body Diagnosis tool for disease agents or body-fluid-borne markers

詳細技術說明: Current methods to remove unwanted agents from bodily fluids (e.g. plasmapheresis) do not occur real-time and induce negative side effects such as transfusion reactions and clotting complications. Other methods such as dialysis fail to remove many targets of high interest such as pathogens, viruses, bacteria, cytokines, cell lines, proteins, endotoxins, and particulates. Researchers at the University of California, Davis have developed a novel system using nanotechnology to synthetically replicate the body's immune function. The method involves the binding of a wide range of targets to nanoparticles over which bodily fluids are passed for filtration, diagnostic, or immune stimulation functions. Initial results using particles coated with CD14 antibody in rhesus macaques successfully resulted in the conversion of target monocytes to functional macrophages. This result demonstrates the immune modulation properties of the system as well as the possibility of manipulating captured cell lines that retain functionality for further therapeutic use. It also demonstrates the novel possibility of using cross-species targets to generate an immune response which is achievable because of the external presentation of the targets.

*Abstract: Researchers at the University of California, Davis have developed a system to synthetically replicate the body's immune function.

*Principal Investigation: Name: Angela Courtney
Department:

Name: Abigail Spinner
Department:

欲了解更多信息，請點擊這裡