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Genetic Test for Determining Blood Type in Domestic Cats

Technology Benefits

Even though accurate tests are readily available to determine feline blood types, the development of a genetic test has the following advantages: The identification of the B-type allele carrier is especially useful for cat breeders in selecting matings to avoid NI complications. The genetic test is non-invasive and can be performed on very young kittens.  It can be performed from a buccal swab and does not require a blood draw.

Technology Application

This genetic test can be used for typing domestic cat blood.

Detailed Technology Description

Domestic cats have one major blood group system with three different types: A, B and the rare AB. The two major serotypes are blood type A and type B, with type A dominant to type B. The rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood typing is important mainly for two reasons: to avoid neonatal isoerythrolysis (NI) that can occur in newborn kittens, and to avoid reactions for blood incompatibility when the cat needs a blood transfusion. These reactions, which may vary in severity from mild to fatal, are due to naturally occurring antibodies. Thus, prevention of NI and transfusion reactions requires close monitoring of blood types. Researchers at the University of California, Davis have identified a series of mutations in the gene CMAH that distinguish type A from type B and are 100% concordant with all cats serotyped. Furthermore, UC Davis researchers have developed a genetic test to distinguish between the blood type A cats and the ones that are carriers for the B blood type allele, which is impossible with serological tests.

Supplementary Information

Patent Number: US7985543B2
Application Number: US2007963220A
Inventor: Lyons, Leslie A. | Pedersen, Niels C. | Bighignoli, Barbara | Niini, Tirri
Priority Date: 21 Dec 2006
Priority Number: US7985543B2
Application Date: 21 Dec 2007
Publication Date: 26 Jul 2011
IPC Current: C07H002104 | C12Q000168
US Class: 43500612 | 435006 | 4350911 | 4350912 | 5360231 | 5360243
Assignee Applicant: The Regents of the University of California
Title: Test for determining blood type in the cat
Usefulness: Test for determining blood type in the cat
Summary: The methods are useful for distinguishing blood type in a cat, and for identifying a blood type B carrier in the cat (all claimed).

Industry

Agriculture

Sub Category

Animal

Application No.

7985543

Others

Related Materials

Bighignoli B, Niini T, Grahn RA, Pedersen NC, Millon LV, Polli M, Longeri M and Lyons LA. 2007. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group. BMC Genet. 8(1):27.
Also see The Lyons' Den at http://www.vetmed.ucdavis.edu/Catgenetics/Index.htm

Related Technologies

• Carrier Tests for Point-Restriction Coat Color in the Domestic Cat
• Feline Calicivirus Vaccine
• Tests for Polycystic Kidney Disease in Domestic Cats

Additional Technologies by these Inventors

• Feline Calicivirus Vaccine
• Tests for Polycystic Kidney Disease in Domestic Cats
• Carrier Tests for Point-Restriction Coat Color in the Domestic Cat

Tech ID/UC Case

11251/2007-264-0

Related Cases

2007-264-0

*Abstract

Identification of Mutations in the Gene CMAH that causes the Cat Blood Type B

*IP Issue Date

Jul 26, 2011

*Principal Investigator

Name: Barbara Bighignoli

Department:

Name: Leslie Lyons

Department:

Name: Tirri Niini

Department:

Name: Niels Pedersen

Department:

Country/Region

USA