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Genetic Test for Determining Blood Type in Domestic Cats

技术优势

Even though accurate tests are readily available to determine feline blood types, the development of a genetic test has the following advantages: The identification of the B-type allele carrier is especially useful for cat breeders in selecting matings to avoid NI complications. The genetic test is non-invasive and can be performed on very young kittens. It can be performed from a buccal swab and does not require a blood draw.

技术应用

This genetic test can be used for typing domestic cat blood.

详细技术说明

Domestic cats have one major blood group system with three different types: A, B and the rare AB. The two major serotypes are blood type A and type B, with type A dominant to type B. The rare type AB may also be allelic and is suspected to be recessive to A and dominant to B. Cat blood typing is important mainly for two reasons: to avoid neonatal isoerythrolysis (NI) that can occur in newborn kittens, and to avoid reactions for blood incompatibility when the cat needs a blood transfusion. These reactions, which may vary in severity from mild to fatal, are due to naturally occurring antibodies. Thus, prevention of NI and transfusion reactions requires close monitoring of blood types. Researchers at the University of California, Davis have identified a series of mutations in the gene CMAH that distinguish type A from type B and are 100% concordant with all cats serotyped. Furthermore, UC Davis researchers have developed a genetic test to distinguish between the blood type A cats and the ones that are carriers for the B blood type allele, which is impossible with serological tests.

附加资料

Patent Number: US7985543B2
Application Number: US2007963220A
Inventor: Lyons, Leslie A. | Pedersen, Niels C. | Bighignoli, Barbara | Niini, Tirri
Priority Date: 21 Dec 2006
Priority Number: US7985543B2
Application Date: 21 Dec 2007
Publication Date: 26 Jul 2011
IPC Current: C07H002104 | C12Q000168
US Class: 43500612 | 435006 | 4350911 | 4350912 | 5360231 | 5360243
Assignee Applicant: The Regents of the University of California
Title: Test for determining blood type in the cat
Usefulness: Test for determining blood type in the cat
Summary: The methods are useful for distinguishing blood type in a cat, and for identifying a blood type B carrier in the cat (all claimed).