AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

Cofactor-free, Inexpensive, Rapid Liver Microsomal Bioreactor for Examining Drug Metabolism and Inhibition and Green Synthesis of Drug Metabolites

Summary

The inventors of this technology have developed an LM bioreactorthat uses a novel, unique electrode surface coated with LMs. This reactor useselectrocatalysis to drive metabolic reactions and does not require expensivecofactors or purification of enzymes. Importantly, these inventors havedesigned the bioreactor to achieve highly enhanced metabolite production, and electrocatalyticstability and reusability. Proof of concept testing with testosterone has alreadydemonstrated that this LM bioreactor exhibits enhanced testosterone hydroxylation,reusability and stability with a half-life of 10 hours.

Technology Benefits

· Reusable · Long half-life in the electrocatalytically active form· Does not require expensive cofactors· Driven by electrocatalysis

Technology Application

· Green synthesis of drug metabolites· Analysis of drug metabolism· Analysis of inhibition of liver function

Detailed Technology Description

None

Country/Region

USA

For more information, please click Here