Cofactor-free, Inexpensive, Rapid Liver Microsomal Bioreactor for Examining Drug Metabolism and Inhibition and Green Synthesis of Drug Metabolites
The inventors of this technology have developed an LM bioreactorthat uses a novel, unique electrode surface coated with LMs. This reactor useselectrocatalysis to drive metabolic reactions and does not require expensivecofactors or purification of enzymes. Importantly, these inventors havedesigned the bioreactor to achieve highly enhanced metabolite production, and electrocatalyticstability and reusability. Proof of concept testing with testosterone has alreadydemonstrated that this LM bioreactor exhibits enhanced testosterone hydroxylation,reusability and stability with a half-life of 10 hours.
· Reusable · Long half-life in the electrocatalytically active form· Does not require expensive cofactors· Driven by electrocatalysis
· Green synthesis of drug metabolites· Analysis of drug metabolism· Analysis of inhibition of liver function
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美国
