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Organ transplant biomarker using donor-reactive T-cell receptors determine donor-host tolerance

Summary

Megan Sykes, M.D.

Technology Benefits

Monitors tolerance and rejection for blood, bone marrow, and end-organ transplants.Uses TCRs as biomarkers, which are independent of other markers and methods of diagnosing organ rejection and tolerance. Identifies unique donor-reactive TCRs sequences for individual transplant patients. Tracks levels of multiple donor-reactive TCRs.Distinguishes between deletional and anergy mechanisms of organ tolerance.Uses standard biomedical diagnostic techniques (cell culture, fluorescence, gene amplification and sequencing) to identify and monitor levels of donor-reactive TCRs.Allows the development individualized post-transplant management strategies for organ recipients. Patent information:Patent Pending

Technology Application

Identify donor reactive T-cell receptors in organ transplant recipients.Track the population of donor-reactive T-cell receptors to identify organ transplant rejection or tolerance.Evaluate compatibility between organ transplant donors and recipients.

Detailed Technology Description

Megan Sykes, M.D.

Country/Region

USA

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