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Organ transplant biomarker using donor-reactive T-cell receptors determine donor-host tolerance

總結

Megan Sykes, M.D.

技術優勢

Monitors tolerance and rejection for blood, bone marrow, and end-organ transplants.Uses TCRs as biomarkers, which are independent of other markers and methods of diagnosing organ rejection and tolerance. Identifies unique donor-reactive TCRs sequences for individual transplant patients. Tracks levels of multiple donor-reactive TCRs.Distinguishes between deletional and anergy mechanisms of organ tolerance.Uses standard biomedical diagnostic techniques (cell culture, fluorescence, gene amplification and sequencing) to identify and monitor levels of donor-reactive TCRs.Allows the development individualized post-transplant management strategies for organ recipients. Patent information:Patent Pending

技術應用

Identify donor reactive T-cell receptors in organ transplant recipients.Track the population of donor-reactive T-cell receptors to identify organ transplant rejection or tolerance.Evaluate compatibility between organ transplant donors and recipients.

詳細技術說明

Megan Sykes, M.D.

*Abstract

None

*Inquiry

Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU13302

*Principal Investigation

*Publications

H. Morris, Y. Shen, T. Kawai, H. Robins, M. Sykes. Role of Deletion of Donor-Reactive T Cells in Maintaining Human Allograft Tolerance Achieved via Combined Kidney and Bone Marrow Transplantation. 2013 American Transplant Congress, Abstract D1761, presented May 21, 2013.

國家/地區

美國