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Micro-scale pillared surfaces with variable rigidity to monitor cellular responses

Summary: This technology is a lithographic technique to pattern surfaces with microscale pillars of varying rigidity to monitor cellular responses to various culture surfaces.

Technology Benefits: Precise control of micropillar rigidity through electron beam exposureConsistent pillar dimensions while varying rigidityCell differentiation controlled at the micro-levelNon-invasiveBiocompatible polymers

Technology Application: Stem cell researchMicrochip construction and designMEMS/NEMS fabrication

Detailed Technology Description: None

*Abstract: None

*Inquiry: Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: m08-073

*Principal Investigator

*Publications: Biggs MJP, Fernandex M, Thomas D, Cooper R, Palma M, Liao J, Fazio T, Dahlberg C, Wheadon H, Pallipurath, A, Pandit A, Kysar J, Wind SJ. “The Functional Response of Mesenchymal Stem Cells to Electron-Beam Patterned Elastomeric Surfaces Presenting Micrometer to Nanoscale Heterogeneous Rigidity”. Adv. Mater. 2017 Sept 1; 29(39): 1702119Tech Ventures Reference:IR M08-073Licensing Contact: Beth Kauderer

*Web Links: WIPO: WO/2009/123739

Country/Region: USA

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