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Recombinant Human Follicle Stimulating Hormone Antagonists and Methods in Cancer Therapy

Technology Benefits: This antagonist is a competitive inhibitor of the FSH receptor.rFSH-Ant can be produced using standard molecular biology and recombinant protein technologies.May be administered by a variety of routes, including intravenously, orally, locally and transdermally.

Technology Application: Therapy for cancers that secrete or respond to FSH, such as epithelial ovarian cancer. ContraceptiveTreatment for ovarian hyperstimulation syndrome (OHSS).

Detailed Technology Description: The present invention comprises of recombinant human follicle stimulating hormone antagonist (rFSH-Ant) in which one or more N-glycosylation sites is disrupted. rFSH-Ant binds to the FSH receptor without activating it, thereby acting as a competitive...

*Abstract: None

*Inquiry: Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR: 2232

*Principal Investigator

*Publications: Ruman JI, Pollak S, Trousdale RK, Klein J, Lustbader JW. Effects of long-acting recombinant human follicle-stimulating hormone analogs containing N-linked glycosylation on murine folliculogenesis. Fertil Steril. 2005;83S1:1303-9

Country/Region: USA

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