Recombinant Human Follicle Stimulating Hormone Antagonists and Methods in Cancer Therapy
- 技术优势
- This antagonist is a competitive inhibitor of the FSH receptor.rFSH-Ant can be produced using standard molecular biology and recombinant protein technologies.May be administered by a variety of routes, including intravenously, orally, locally and transdermally.
- 技术应用
- Therapy for cancers that secrete or respond to FSH, such as epithelial ovarian cancer. ContraceptiveTreatment for ovarian hyperstimulation syndrome (OHSS).
- 详细技术说明
- The present invention comprises of recombinant human follicle stimulating hormone antagonist (rFSH-Ant) in which one or more N-glycosylation sites is disrupted. rFSH-Ant binds to the FSH receptor without activating it, thereby acting as a competitive...
- *Abstract
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None
- *Inquiry
- Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- 2232
- *Principal Investigation
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- *Publications
- Ruman JI, Pollak S, Trousdale RK, Klein J, Lustbader JW. Effects of long-acting recombinant human follicle-stimulating hormone analogs containing N-linked glycosylation on murine folliculogenesis. Fertil Steril. 2005;83S1:1303-9
- 国家/地区
- 美国
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