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Compositions and Methods for Treating Mammary Tumors

Technology Benefits: Potential therapeutic for anti-estrogen resistant cancersCan restore sensitivity to Tamoxifen and FulvestrantCan be used alone or in conjunction with Tamoxifen

Detailed Technology Description: Resistance to anti-estrogenic therapies remains as a very significant problem in the treatment of breast cancer. The present invention describes small molecules for the treatment or prevention of breast cancer. These compounds are effective against anti-estrogen resistant cells, and most remarkably, restore the sensitivity of Tamoxifen and Fulvestrant-resistant cells to Tamoxifen and Fulvestrant.

*Abstract: None

*Publications: Manuscript in preparation.

*Stage of Development: Researchers have identified compounds that inhibit ER-α activity in multiple cell lines. Mechanism of action studies have been completed.

Country/Region: USA

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