Creating Chiral Organoalanes and Organic Derivatives
- Summary
- Researchers at Purdue University have developed a method that uses Zr-catalyzed asymmetric carboalumination of alkenes to produce chiral alkylalanes. These chiral alkylalanes can then be converted to various chiral organic compounds, such as isoalkyl alcohols and other organic compounds of interest, which can then be used in the production of vitamins, pharmaceuticals, and other medicinally and biologically important compounds. This process also yields isoalkyl alcohols with a high enantiomeric excess (e.e.), often exceeding 95% e.e.
- Technology Benefits
- Can be used in production of various organic compounds of interestYields isoalkyl alcohols with high enantiomeric excess
- Technology Application
- Chemical AnalysisPhamaceuticalsMedical/Healthcare
- Detailed Technology Description
- Ei-ichi NegishiPurdue Chemistry
- Countries
- United States
- Application No.
- 6,002,037
- *Abstract
-
- *Background
- Catalytic enantioselective carbon-carbon bond formation is a highly desirable but difficult synthetic task when it involves simple alkenes without heteroatom function groups.
- *IP Issue Date
- Dec 14, 1999
- *IP Type
- Utility
- *Stage of Development
- Process Validation in Lab
- *Web Links
- Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipEi-ichi NegishiPurdue Chemistry
- Country/Region
- USA
For more information, please click Here
