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High-Throughput Optical Deformability Measurement of Cells

Technology Benefits

Main Advantages of this InventionΓÇó More sensitive than most methodsΓÇó Ability to use in a dynamic, flowing systemΓÇó DoesnΓÇÖt require careful storage or the disposal of cytotoxic reagents

Technology Application

Potential Areas of Application ΓÇó Medical research ΓÇó Medical diagnostics

Detailed Technology Description

None

Supplementary Information

Inventor: Squier, Jeff | Marr, David W. M. | Applegate, Robert | Vestad, Tor | Chichester, Justin
Priority Number: US8119976B2
IPC Current: H01S000100
US Class: 250251 | 4351739
Assignee Applicant: Colorado School of Mines,Golden
Title: Optical-based cell deformability
Usefulness: Optical-based cell deformability
Summary: Method for changing orientation of an object such as cell, bead, colloid and particle (claimed) in executing tissue engineering and colloidal synthesis. Can also be used for blood cell, fetal cell, sickle cell and pollutant.
Novelty: Object's e.g. cell, orientation changing method for e.g. tissue engineering, involves illuminating objects with single beam of electromagnetic radiation sufficient to change orientation of objects from one orientation to another orientation

Industry

Measurement/Testing

Sub Category

Measurement Tool

*Abstract

This invention provides a method to measure cell deformability in a dynamic, flowing system, using an integration of novel laser configurations within a microfluidic system. This optical stretching is able to distinguish between normal, cancerous and metastatic mouse fibroblast and human breast epithelial cells. A correlation between this method and other methods used has been observed, with the new method being more sensitive in identify specific cell types.

*Principal Investigator

Name: David Marr

Department:

Name: Jeff Squier

Department:

Name: Rob Applegate

Department:

Name: Tor Vestad

Department:

Country/Region

USA