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High-Throughput Optical Deformability Measurement of Cells

技術優勢

Main Advantages of this InventionΓÇó More sensitive than most methodsΓÇó Ability to use in a dynamic, flowing systemΓÇó DoesnΓÇÖt require careful storage or the disposal of cytotoxic reagents

技術應用

Potential Areas of Application ΓÇó Medical research ΓÇó Medical diagnostics

詳細技術說明

None

*Abstract

This invention provides a method to measure cell deformability in a dynamic, flowing system, using an integration of novel laser configurations within a microfluidic system. This optical stretching is able to distinguish between normal, cancerous and metastatic mouse fibroblast and human breast epithelial cells. A correlation between this method and other methods used has been observed, with the new method being more sensitive in identify specific cell types.

*Principal Investigation

Name: David Marr

Department:

Name: Jeff Squier

Department:

Name: Rob Applegate

Department:

Name: Tor Vestad

Department:

附加資料

Inventor: Squier, Jeff | Marr, David W. M. | Applegate, Robert | Vestad, Tor | Chichester, Justin
Priority Number: US8119976B2
IPC Current: H01S000100
US Class: 250251 | 4351739
Assignee Applicant: Colorado School of Mines,Golden
Title: Optical-based cell deformability
Usefulness: Optical-based cell deformability
Summary: Method for changing orientation of an object such as cell, bead, colloid and particle (claimed) in executing tissue engineering and colloidal synthesis. Can also be used for blood cell, fetal cell, sickle cell and pollutant.
Novelty: Object's e.g. cell, orientation changing method for e.g. tissue engineering, involves illuminating objects with single beam of electromagnetic radiation sufficient to change orientation of objects from one orientation to another orientation

主要類別

測量/測試

細分類別

測量工具

國家/地區

美國