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Small Molecure Inhibitors of Dusp6

Detailed Technology Description: None

*Abstract: Dusp6 is a protein that limits the expression of fibroblast growth factor (FGF) causing slowed cell division, making it a target for controlling cell growth. Investigators have developed compounds which effectively inhibit Dusp6 and promote the expression of FGF as shown in a zebra fish model.Applications* Treating wounds* Expanding cells* Growing tissues in vitroAdvantages* Novel compound that stimulates cell growthStage of DevelopmentProof of concept in vivo (zebrafish model) with initial hits and follow on compounds.

*Principal Investigator: Name: Billy Day, Professor
Department: Pharm-Pharmaceutical Science

Name: Vasily Korotchenko
Department: Pharm-Pharmaceutical Science

Name: Michael Wai Kok Tsang
Department: Med-Developmental Biology

Country/Region: USA

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