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A-24 Enzymatic Assay of D-serine

Technology Benefits
●　Simple: No complicated pre-treatment is needed●　Precise: Almost free from L-amino acid noise ●　Easy: No high proficiency required to analyze the data●　Efficient: Large quantity of sample can be processed in bulk●　Safe: Disposable; no infection risk●　Cheap: Expensive instruments used in High-performance liquid chromatography (HPLC), capillary electrophoresis, or gas chromatography are not needed
Technology Application
D-Serine Assay, Diagnostic Kit for Schizophrenia and AlzheimerΓÇÖs Disease
Detailed Technology Description
None
Supplementary Information
Inventor: YOSHIMURA, Tohru | ITO, Tomokazu
Priority Number: WO2008047802A1
IPC Current: C12N001500 | C12N000115 | C12N000119 | C12N000121 | C12N000510 | C12N000988 | C12N001509 | C12Q0001527
Assignee Applicant: National University Corporation Nagoya University
Title: D-SERINE DEHYDRATASE AND USE THEREOF | D-SÉRINE DÉSHYDRATASE ET SON UTILISATION
Usefulness: D-SERINE DEHYDRATASE AND USE THEREOF | D-SÉRINE DÉSHYDRATASE ET SON UTILISATION
Summary: The protein having D-serine dehydratase activity is useful as reagent for quantifying D-serine (all claimed), for diagnosing schizophrenia, Alzheimer's disease or bovine spongiform encephalopathy (BSE).
Novelty: Novel protein having D-serine dehydratase activity, useful as reagent for quantifying D-serine for diagnosing schizophrenia, Alzheimer's disease or bovine spongiform encephalopathy
Industry
Biomedical
Sub Category
DNA/Gene Engineering
*Abstract
Researchers at Nagoya University found a novel enzyme, D-serine dehydratase, which can be used to measure the D-serine. The quantification methods consists of (1) reacting the sample with D-serine dehydratase to decompose D-serine into pyruvic acid or ammonia, (2) measuring pyruvic acid by using lactate dehydrogenase; or measuring ammonia by using pyruvate oxidase, and (3) quantifying D-serine via the data obtained in (2)
*Principal Investigator

Name: Tohru Yoshimura, Ph.D., Professor

Department: Applied Molecular Biosciences, Graduate School of Biological Science, School of Agricultural Sciences, Nagoya University

Country/Region
USA

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