A-11 Neuronal Cell Death Inhibitor and Screening Method
- Technology Benefits
- Useful to search new compounds suppressing neuronal damage in a various conditions.The newly synthesized carbenoxoloneprodrug(Compound B) effectively suppressed glutamate release by activated microglia, and suppressed microglialneruotoxicity. Compound B could ameliorate disease progression of model animals for various neurodegeneration. The compound, thus, could be a candidate for treating neuronal degeneration in a variety of neurological disorders.
- Detailed Technology Description
- None
- Supplementary Information
- Inventor: LEE, DANIEL H S | SAH, DINAH W Y | SO, KWOK FAI | WU, WUTIAN
Priority Number: CN101426512A
IPC Current: A61K003800 | A01N003718 | A01N006100
Assignee Applicant: Biogen Idec Ma Inc. |The University of Hong Kong
Title: Methods of treating conditions involving neuronal degeneration | Method of treating diseases referring to neuronal degeneration
Usefulness: Methods of treating conditions involving neuronal degeneration | Method of treating diseases referring to neuronal degeneration
Summary: The methods are useful for promoting regeneration or survival of a sensory neuron in a mammal displaying signs or symptoms of a condition involving neuronal cell death, and for treating hearing loss or an optical neuropathy in a mammal (claimed).
- Industry
- Disease Diagnostic/Treatment
- Sub Category
- Other Disease
- *Abstract
-
The technology provides a neuronal cell death inhibitor comprising a compound having an inhibitory activity on the production and/or release of glutamate in activated microglia. In contrast to na├¤ve cells, activated microglia produce glutamate with glutaminase and release it through gap-junction. By inhibiting the production and/or release of glutamate in microglia with either glutaminase or gap-junction inhibitors, neuritic bead-like degeneration or neuronal cell death can be inhibited. With the screening method, we have synthesized several compounds using above inhibitors as lead compounds.
- Country/Region
- USA
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