Synthesis of 1-[p-Nitrophenyl]3-Methyl-4-oxo-benzopyranyl[4,3-c] Pyrazoline by green chemistry
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- Summary
- novel, simple, economic, high % of yield and ecofriendly seriesof compounds biologicaly active as cytotoxic
- Technology Benefits
- only single step for synthesis (green chemistry)of anticancer candidate; 7-8 times more active than 5-flourouracil as anticancer
- Technology Application
- Medicinal green chemistry
- Detailed Technology Description
- Rational drug resign by fusing two biologically active motif as anticancer: coumarin with pyrazoline pharmacophore are successifly synthesized by using ultrasound waves (ecofriendly method) and convential method (simple condensation of 3-acetyle coumarine with hydrazine( or their derivatives) to give series of heterocyclic and biological active compounds in one or two steps only; cytotoxic screening using highly sensitive ATP biolumiscent method, explored highly cytotoxic novel series of compounds.
- Type of Cooperation
- Licensing
- Application Date
- 22/6/2016
- Application No.
- 2015/306
- Classes
- A61K31/015
- Others
- No CN patents
- ID No.
- 4615
- Country/Region
- Iraq
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