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Synthesis of 1-[p-Nitrophenyl]3-Methyl-4-oxo-benzopyranyl[4,3-c] Pyrazoline by green chemistry

總結: novel, simple, economic, high % of yield and ecofriendly seriesof compounds biologicaly active as cytotoxic

技術優勢: only single step for synthesis (green chemistry)of anticancer candidate; 7-8 times more active than 5-flourouracil as anticancer

詳細技術說明: Rational drug resign by fusing two biologically active motif as anticancer: coumarin with pyrazoline pharmacophore are successifly synthesized by using ultrasound waves (ecofriendly method) and convential method (simple condensation of 3-acetyle coumarine with hydrazine( or their derivatives) to give series of heterocyclic and biological active compounds in one or two steps only; cytotoxic screening using highly sensitive ATP biolumiscent method, explored highly cytotoxic novel series of compounds.

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