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EF-Tu-binding Re-complexed antibiotics

Summary

EF-Tu-binding Re-complexed antibiotics against Gram-positive bacteria.

Technology Benefits

Novel antibiotic class
Activity against Gram-positive Bacteria
Inhibits translation – a validated target

Technology Application

therapeutic development

Detailed Technology Description

The complexes were found to exhibit potent antimicrobial activity against gram-positive bacterial strains in the low micromolar concentration range, rendering these compounds interesting lead structures for the development of novel metal-based antibiotic agents.Anti-Gram-positive activity:
Substances have good activity against Bacillus subtilis and Staphylococcus aureus.Validated target:
Protein biosynthesis inhibition was observed and EF-Tu identified as target protein.

Type of Cooperation

Licensing

Application Date

07/07/2017 00:00:00

Application No.

WO2018EP66100 20180618

Classes

- international:
A61K31/4184; A61K31/4188; A61P31/04; C07F13/00
- cooperative:
A61K47/547; A61P31/04; C07D235/04; C07F13/00; G01N33/68

Others

Patent application

ID No.

5200

Country/Region

Germany

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