EF-Tu-binding Re-complexed antibiotics
EF-Tu-binding Re-complexed antibiotics against Gram-positive bacteria.
Novel antibiotic class
Activity against Gram-positive Bacteria
Inhibits translation – a validated target
therapeutic development
The complexes were found to exhibit potent antimicrobial activity against gram-positive bacterial strains in the low micromolar concentration range, rendering these compounds interesting lead structures for the development of novel metal-based antibiotic agents.Anti-Gram-positive activity:
Substances have good activity against Bacillus subtilis and Staphylococcus aureus.Validated target:
Protein biosynthesis inhibition was observed and EF-Tu identified as target protein.
Licensing
07/07/2017 00:00:00
WO2018EP66100 20180618
- international:
A61K31/4184; A61K31/4188; A61P31/04; C07F13/00
- cooperative:
A61K47/547; A61P31/04; C07D235/04; C07F13/00; G01N33/68
Patent application
5200
德国
