EF-Tu-binding Re-complexed antibiotics
- 总结
- EF-Tu-binding Re-complexed antibiotics against Gram-positive bacteria.
- 技术优势
- Novel antibiotic class
Activity against Gram-positive Bacteria
Inhibits translation – a validated target
- 技术应用
- therapeutic development
- 详细技术说明
- The complexes were found to exhibit potent antimicrobial activity against gram-positive bacterial strains in the low micromolar concentration range, rendering these compounds interesting lead structures for the development of novel metal-based antibiotic agents.Anti-Gram-positive activity:
Substances have good activity against Bacillus subtilis and Staphylococcus aureus.Validated target:
Protein biosynthesis inhibition was observed and EF-Tu identified as target protein.
- 合作类型
- Licensing
- 申请日期
- 07/07/2017 00:00:00
- 申请号码
- WO2018EP66100 20180618
- 分类
- - international:
A61K31/4184; A61K31/4188; A61P31/04; C07F13/00
- cooperative:
A61K47/547; A61P31/04; C07D235/04; C07F13/00; G01N33/68
- 其他
- Patent application
- ID号码
- 5200
- 国家/地区
- 德国
欲了解更多信息，请点击 这里
