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ANG-2

Summary

Angiopoietin-2 predicts the efficacy of angiogenesis inhibitors in colorectal cancer therapy.

Technology Benefits

Ang-2 level as predictive biomarker for angiognese-targeted therapeutical approaches of CRC.
Low pretherapeutic serum Ang-2 levels are associated with: reduced risk of death, increased progression-free survival.

Technology Application

Cancer Therapy- Strong diagnostic potential of the predictive biomarker has been demonstrated in pretherapeutic blood samples from colorectal cancer patients vs. healthy controls

Detailed Technology Description

A novel predictive biomarker to help identify the patient population with the most favorable clinical outcome to angiogenesis-targeted treatment in mCRC patients.Experiments revealed that patients with low pretherapeutic Ang-2 serum levels receiving a bevacizumab-containing treatment were associated with a better response rate compared to patients with high pretherapeutic Ang-2 levels

Type of Cooperation

Licensing

Application Date

06/09/2010 00:00:00

Application No.

EP20100757580 20100906

Classes

- international:
G01N33/68
- cooperative:
G01N33/57419; G01N2333/515; G01N2800/52; G01N2800/56

Others

Patent application

ID No.

2262

Country/Region

Germany

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