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Muscle Progenitor Cells Enhance Innervation

Summary

A Purdue University researcher has developed a toolkit and a method for repairing and reconstructing a damaged or nonfunctional muscle using in vitro primed muscle progenitor cells to promote innervation of the damaged or nonfunctional muscle without any genetic manipulation. Muscle progenitor cells are harvested and grown to a critical mass in culture. The cells are then injected into the damaged or nonfunctional muscle and fuse with native muscle fiber. Following the injection, the muscle is innervated, atrophy has been shown to reverse, and the muscle fibers have an increased force of contraction.

Technology Benefits

Does not use genetically modified cells Allows the body to naturally regrow nerve connections Clinically translatable

Technology Application

Innervation Muscle repair Tissue engineering

Detailed Technology Description

Stacey HalumThe Voice Clinic of IndianaPurdue Speech, Language, & Hearing Sciences

Countries

United States

Application No.

None

Country/Region

USA

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