Non-Human Primate Adenovirus Model of Human Respiratory Disease
Model for respiratory disease Cross-species adenovirus Novel viral species
Detect, treat, prevent, and modulate adenovirus infection
Adenoviruses, or double-stranded DNA viruses that naturally infect vertebrates, have been associated with clinical syndromes including conjunctivitis, hepatitis, and diarrhea. Conventionally, these viruses are thought to be species specific. A high degree of sequence relatedness however suggests that at least some adenoviral strains may be capable of infecting both human and nonhuman primates. These adenovirus can then be used to create models of human diseases in nonhuman primates. Researchers at the University of California, Davis have discovered an adenovirus from titi monkeys with the potential to infect both human and non-human primates, including both titi monkeys and common marmosets. The researchers have developed methods to detect the adenovirus infection. Furthermore, the virus has been successfully cultivated in a human lung adenocarcinoma cell line and a primary titi monkey cell line, presenting a potential human lung disease model in nonhuman primates.
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Related Materials Chen EC, Yagi S, Kelly KR, et al. Cross-Species Transmission of a Novel Adenovirus Associated with a Fulminant Pneumonia Outbreak in a New World Monkey Colony. Nemerow GR, ed. PLoS Pathogens. 2011;7(7):e1002155. doi:10.1371/journal.ppat.1002155. Tech ID/UC Case 27612/2011-441-0 Related Cases 2011-441-0
Yu G, Yagi S, Carrion R Jr, et al. Experimental cross-species infection of common marmosets by titi monkey adenovirus. PLoS One 2013; 8(7) e68558. doi: 10.1371/journal.pone.006558.
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